(R)-(+)-N-乙酰基-甲基苄胺合成路线 （共 87 条）
反应条件
1: CH2Cl2 / 12 h / Ambient temperature 2: 89 percent / diethyl ether / 6 h / 0 °C 3: 81 percent / Et3N / CH2Cl2 / 12 h / Ambient temperature 4: BBr3 / benzene / 6 h / Heating 5: MnO2, MgSO4 / ethyl acetate / 12 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 55, # 21 p. 6453 - 6464
反应条件
1: 81 percent / Et3N / CH2Cl2 / 12 h / Ambient temperature 2: BBr3 / benzene / 6 h / Heating 3: MnO2, MgSO4 / ethyl acetate / 12 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 55, # 21 p. 6453 - 6464
反应条件
1: BBr3 / benzene / 6 h / Heating 2: MnO2, MgSO4 / ethyl acetate / 12 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 55, # 21 p. 6453 - 6464
反应条件
2: aq. Na2CO3 / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 50, # 34 p. 10309 - 10320
反应条件
T=200°C; P=3750.3 Torr; 0.166667 h; microwave irradiation;
参考文献
Gelens, Edith; Smeets, Luc; Sliedregt, Leo A.J.M.; Van Steen, Bart J.; Kruse, Chris G.; Leurs, Rob; Orru, Romano V.A.
Tetrahedron Letters, 2005 , vol. 46, # 21 p. 3751 - 3754
反应条件
in tetrahydrofuran; acetonitrile T=-20°C; 40 h; Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 57, # 45 p. 9309 - 9315
反应条件
N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 24 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 43, # 25 p. 3314 - 3317
反应条件
Candida antarctica lipase B (CAL-B) immobilized on resin EXE 120 in tert-butyl methyl ether 18 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Process Research and Development, , vol. 15, # 5 p. 1033 - 1035
反应条件
1.1: hydroxylamine hydrochloride / water; methanol / 25 °C 2.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 3.2: 18 h / 20 °C 4.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere 5.1: triethylamine; 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 11 p. 5314 - 5327
反应条件
1.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 2.2: 18 h / 20 °C 3.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere 4.1: triethylamine; 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 11 p. 5314 - 5327
