4-(4-氯苯基)-4-羟基哌啶合成路线 （共 28 条）
反应条件
sodium carbonate in 1,4-dioxane; water
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/35143 A1, 2012 ;
反应条件
sodium carbonate; sodium iodide in acetonitrile Reflux;
参考文献
Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5259 - 5263
反应条件
hydrogenchloride; potassium hydroxide; potassium iodide in water; isopropyl alcohol
参考文献
G. D. Searle and Co.
Patent: US4086234 A1, 1978 ;
反应条件
N-ethyl-N,N-diisopropylamine in methanol; dichloromethane; acetonitrile
参考文献
Pike, Victor W.; Innis, Robert B.; Zoghbi, Sami S.; Lazarova, Neva
Patent: US2009/274624 A1, 2009 ;
反应条件
potassium iodide in toluene T=125°C; 25 h;
参考文献
Leyva-Perez, Antonio; Cabrero-Antonino, Jose R.; Rubio-Marques, Paula; Al-Resayes, Saud I.; Corma, Avelino
ACS Catalysis, 2014 , vol. 4, # 3 p. 722 - 731
反应条件
1: 78 percent / acetic acid; NaCNBH3 / methanol / 30 h / 20 °C 2: 65 percent / conc. HCl / methanol / 2 h / Heating View Scheme
参考文献
Moerlein, Stephen M.; Stoecklin, Gerhard L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1319 - 1324
反应条件
sodium carbonate in N,N-dimethyl-formamide T=80°C;
参考文献
Chen, Zhengming; Davies, Ellen; Miller, Wendy S.; Shan, Shen; Valenzano, Kenneth J.; Kyle, Donald J.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5275 - 5279
反应条件
hydrogenchloride; potassium iodide; potassium hydrogencarbonate in methanol; water; toluene
参考文献
G. D. Searle and Co.
Patent: US4086234 A1, 1978 ;
参考文献
Sato; Uchimaru
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 11 p. 3134 - 3144
反应条件
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / |Inert atmosphere; |Schlenk technique
2: potassium hydroxide / tert-butyl alcohol / 72 h / 100 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Bao, Xiaofeng; Liu, Duliang; Jin, Yanyan; Yang, Yao
Molecules, 2012 , vol. 17, # 12 p. 14288 - 14297
