3-溴-2,2-二甲基-1-丙醇合成路线 （共 29 条）
反应条件
pyridine; bromine; triphenylphosphine in chloroform 12 h; Ambient temperature;
参考文献
Dale, Johannes; Fredriksen, Siw B.
Acta Chemica Scandinavica, 1991 , vol. 45, # 1 p. 82 - 91
反应条件
carbon tetrabromide in dichloromethane-d2 T=20°C; 96 h;
参考文献
Billing, Peter; Brinker, Udo H.
Journal of Organic Chemistry, 2012 , vol. 77, # 24 p. 11227 - 11231
反应条件
ethanol; hydrogen bromide
参考文献
Searles et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 1839,1842
反应条件
lithium hydroxide; hydrogen bromide; acetic acid 1.) reflux, 8 h, 2.) water, DME, 3 h; Yield given. Multistep reaction;
参考文献
Hua, Duy H.; Venkataraman, S.; Ostrander, Robert A.; Sinai, Gurudas-Z.; McCann, Peggy J.; et al.
Journal of Organic Chemistry, 1988 , vol. 53, # 3 p. 507 - 515
参考文献
Delmond,B. et al.
Journal of Organometallic Chemistry, 1973 , vol. 47, p. 337 - 350
反应条件
hydrogen bromide 8 h; Heating; Title compound not separated from byproducts;
参考文献
Hua, Duy H.; Venkataraman, S.; Ostrander, Robert A.; Sinai, Gurudas-Z.; McCann, Peggy J.; et al.
Journal of Organic Chemistry, 1988 , vol. 53, # 3 p. 507 - 515
参考文献
Szmant; Emerson
Journal of the American Chemical Society, 1956 , vol. 78, p. 454,457
参考文献
Franke
Monatshefte fuer Chemie, 1913 , vol. 34, p. 1904
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=0 - 25°C; 12 h; Inert atmosphere;
参考文献
Principia Biopharma Inc.; Goldstein, David Michael
Patent: US8673925 B1, 2014 ;
Location in patent: Page/Page column 251 ;
反应条件
1: dimethyl sulfoxide / 100 °C 2: hydrogen; ammonium hydroxide / Raney nickel / ethanol; water / 48 h / 760.05 Torr 3: dichloromethane / 2 h / 20 °C View Scheme
参考文献
BELLUS HEALTH (INTERNATIONAL) LIMITED; KONG, Xianqi; LEVENS, Nigel; BOUZIDE, Abderrahim; CIBLAT, Stephane; FRENETTE, Richard; RENAUD, Johanne
Patent: WO2011/17800 A1, 2011 ;
