C-(1-哌啶-1-基-环己基)-甲基胺合成路线 （共 6 条）
反应条件
lithium aluminium tetrahydride; sulfuric acid in tetrahydrofuran; diethyl ether T=0 - 50°C; Reflux;
参考文献
McClure, Kelly J.; Maher, Michael; Wu, Nancy; Chaplan, Sandra R.; Eckert III, William A.; Lee, Dong H.; Wickenden, Alan D.; Hermann, Michelle; Allison, Brett; Hawryluk, Natalie; Breitenbucher, J. Guy; Grice, Cheryl A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5197 - 5201
参考文献
Allen and Hanburys Limited
Patent: US3975443 A1, 1976 ;
反应条件
aluminium hydride in tetrahydrofuran 20 h; Ambient temperature;
参考文献
Costa, Brian R. de; He, Xiao-shu; Linders, Joannes T.M.; Dominguez, Celia; Gu, Zi Qiang; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2311 - 2320
反应条件
1: zinc(II) iodide / methanol; diethyl ether / 8 h / 80 °C 2: lithium aluminium tetrahydride; sulfuric acid / tetrahydrofuran; diethyl ether / 0 - 50 °C / Reflux View Scheme
参考文献
McClure, Kelly J.; Maher, Michael; Wu, Nancy; Chaplan, Sandra R.; Eckert III, William A.; Lee, Dong H.; Wickenden, Alan D.; Hermann, Michelle; Allison, Brett; Hawryluk, Natalie; Breitenbucher, J. Guy; Grice, Cheryl A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5197 - 5201
反应条件
1: zinc(II) iodide / methanol; diethyl ether / 8 h / 80 °C 2: lithium aluminium tetrahydride; sulfuric acid / tetrahydrofuran; diethyl ether / 0 - 50 °C / Reflux View Scheme
参考文献
McClure, Kelly J.; Maher, Michael; Wu, Nancy; Chaplan, Sandra R.; Eckert III, William A.; Lee, Dong H.; Wickenden, Alan D.; Hermann, Michelle; Allison, Brett; Hawryluk, Natalie; Breitenbucher, J. Guy; Grice, Cheryl A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5197 - 5201
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Welvart
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1951 , vol. 233, p. 1121
