2-环己基-2-氧代乙酸合成路线 （共 28 条）
反应条件
potassium permanganate
参考文献
Newman; Owen
Journal of the Chemical Society, 1952 , p. 4713,4717
反应条件
lithium hydroxide; dicobalt octacarbonyl in tert-butyl alcohol
T=80°C; P=37503 Torr;
参考文献
Beisser, Juergen; Fell, Bernhard
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1992 , vol. 334, # 4 p. 355 - 357
反应条件
1: 84 percent / HCl / dioxane / 24 h / 20 °C
2: 75 percent / NaHCO3 / aliquat(R) 336 / toluene / 48 h
3: 26 percent / oxalyl chloride; DMSO; TEA / CH2Cl2 / -60 - 20 °C
4: 78 percent / conc. HCl; H2 / Pd/C / ethanol / 20 °C / atmospheric pressure
View Scheme
参考文献
Roxburgh, Craig J.; Ganellin, C. Robin; Thorpe, Andrew J.
Synlett, 2007 , # 8 p. 1211 - 1214
反应条件
1: 26 percent / oxalyl chloride; DMSO; TEA / CH2Cl2 / -60 - 20 °C
2: 78 percent / conc. HCl; H2 / Pd/C / ethanol / 20 °C / atmospheric pressure
View Scheme
参考文献
Roxburgh, Craig J.; Ganellin, C. Robin; Thorpe, Andrew J.
Synlett, 2007 , # 8 p. 1211 - 1214
反应条件
1.1: NaHSO3; H2O / ethyl acetate / 24 h / 0 °C
1.2: 5 h / 25 °C
2.1: 84 percent / HCl / dioxane / 24 h / 20 °C
3.1: 75 percent / NaHCO3 / aliquat(R) 336 / toluene / 48 h
4.1: 26 percent / oxalyl chloride; DMSO; TEA / CH2Cl2 / -60 - 20 °C
5.1: 78 percent / conc. HCl; H2 / Pd/C / ethanol / 20 °C / atmospheric pressure
View Scheme
参考文献
Roxburgh, Craig J.; Ganellin, C. Robin; Thorpe, Andrew J.
Synlett, 2007 , # 8 p. 1211 - 1214
参考文献
Fissekis et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2715,2717
反应条件
2: 10percent NaOH / 1 h / Heating
View Scheme
参考文献
Luyten, Marcel A.; Bur, Daniel; Wynn, Hla; Parris, Wendy; Glod, Marvin; et al.
Journal of the American Chemical Society, 1989 , vol. 111, # 17 p. 6800 - 6804
反应条件
1: aqueous NaOH
2: aqueous HCl
View Scheme
参考文献
Fissekis et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 2715,2717
反应条件
1: 87 percent
2: OH(1-) / H2O
View Scheme
参考文献
Senanayake, Chris H.; Fang, Kevin; Grover, Paul; Bakale, Roger P.; Vandenbossche, Charles P.; Wald, Stephen A.
Tetrahedron Letters, 1999 , vol. 40, # 5 p. 819 - 822
反应条件
1: 93 percent / CrO3 / acetic acid / 4 h / 80 °C
2: 76 percent / HCl / acetic acid / 11 h / Heating
View Scheme
参考文献
Roxburgh, Craig J.; Ganellin, C. Robin; Shiner, Mark A. R.; Benton, David C. H.; Dunn, Philip M.; Ayalew, Yeshi; Jenkinson, Donald H.
Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 8 p. 851 - 857
