3,4,5-三甲氧基苯甲酰氯合成路线 （共 203 条）
反应条件
in pyridine T=100°C; 1 h;
参考文献
Szantay; Honty; Blasko; et al.
1983 , vol. No. 8, p. 1278 - 1291
反应条件
1: 39 percent / stannic chloride / CH2Cl2 / 22 h 2: 4.5 g / NaOH / ethanol / 14 h / Ambient temperature View Scheme
参考文献
Jones, David W.; Thompson, Adrian M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 21 p. 2533 - 2540
反应条件
1: 1.) ZnCl2 / 1.) Et2O, reflux, 3 h, 2.) benzene, r.t., overnight 2: 98percent hydrazine hydrate / ethanol / 5 h / Heating 3: KOH / 1 h / 180 °C View Scheme
参考文献
Azzena, Ugo; Denurra, Teresa; Melloni, Giovanni; Rassu, Gloria
Journal of the Chemical Society, Chemical Communications, 1987 , p. 1549 - 1550
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=0°C; 1 h;
参考文献
Obrecht, Daniel; Weiss, Bettina
Helvetica Chimica Acta, 1989 , vol. 72, p. 117 - 122
反应条件
pyridine in dichloromethane
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US5248825 A1, 1993 ;
反应条件
1: toluene; hydrogen; palladium-barium sulfate 2: alcohol; KOH-solution / -5 °C / Behandeln des Reaktionsprodukts mit verd. Salzsaeure 3: zinc; sodium amalgam; glacial acetic acid / Reagens4: Alkohol View Scheme
参考文献
Slotta; Heller
Chemische Berichte, 1930 , vol. 63, p. 3029,3043
参考文献
Pagani; Romussi
Bollettino chimico farmaceutico, 1972 , vol. 111, # 7 p. 409 - 416
反应条件
in tetrahydrofuran
1 h; Ambient temperature;
参考文献
Kar
Pharmazie, 1983 , vol. 38, # 5 p. 313 - 315
反应条件
hydrogenchloride; AlCl3 in hexane; dichloromethane; ethyl acetate; methoxybenzene
参考文献
Research Corporation Technologies, Inc.
Patent: US5430062 A1, 1995 ;
反应条件
aluminium trichloride in dichloromethane
6 h; Ambient temperature;
参考文献
Cushman, Mark; Nagatarathnam, Dhanapalan; Gopal, D.; He, Hu-Ming; Lin, Chii M.; Hamel, Ernest
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2293 - 2306
