1: With acetic acid in 1,2-dichloro-ethane T=20°C; 2 h; 2: With sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane T=20°C; 3: With sodium hydrogencarbonate in water; 1,2-dichloro-ethane
参考文献
EVOTEC NEUROSCIENCES GMBH
Patent: WO2009/135842 A1, 2009 ;
Location in patent: Page/Page column 69-70 ;
WO 2009/135842 A1
Mayence, Annie; Vanden Eynde, Jean Jacques; Krogstad, Fran M.; Krogstad, Donald J.; Cushion, Melanie T.; Huang, Tien L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2700 - 2705