3-氧代-3-苯基丙酸叔丁酯合成路线 （共 33 条）
反应条件
1: potassium tert-butoxide / 3 h / Ambient temperature
2: ammonium chloride, 28percent ammonia / H2O / 0.33 h / 42 °C
View Scheme
参考文献
Sato, Masayuki; Ogasawara, Hiromichi; Oi, Keiichi; Kato, Tetsuzo
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 6 p. 1896 - 1901
反应条件
1: water; sodium hydroxide / 20 °C
2: dicyclohexyl-carbodiimide / acetonitrile / 6 h / 20 °C
View Scheme
参考文献
Yoshida, Masanori; Kubara, Ami; Hara, Shoji
Chemistry Letters, 2013 , vol. 42, # 2 p. 180 - 182
反应条件
1.1: lithium hexamethyldisilazane; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / |Inert atmosphere
1.2: 3 h / -78 °C / |Inert atmosphere
2.1: manganese(IV) oxide / dichloromethane / 3 h / |Reflux
View Scheme
参考文献
Prechter, Agnes; Henrion, Guilhem; Faudot Dit Bel, Pierre; Gagosz, Fabien
Angewandte Chemie - International Edition, 2014 , vol. 53, # 19 p. 4959 - 4963
Angew. Chem., 2014 , vol. 126, # 19 p. 5059 - 5063,5
反应条件
1.1: lithium hexamethyldisilazane; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / |Inert atmosphere
1.2: 3 h / -78 °C / |Inert atmosphere
2.1: manganese(IV) oxide / dichloromethane / 3 h / |Reflux
View Scheme
参考文献
Prechter, Agnes; Henrion, Guilhem; Faudot Dit Bel, Pierre; Gagosz, Fabien
Angewandte Chemie - International Edition, 2014 , vol. 53, # 19 p. 4959 - 4963
Angew. Chem., 2014 , vol. 126, # 19 p. 5059 - 5063,5
反应条件
1: 1,5-diphenyl-pentan-1,3,5-trione With bis(acetylacetonate)oxovanadium in benzene
T=20°C;
2: tert.-butylhydroperoxide in benzene
T=20°C; 20 h;
参考文献
Stepovik; Gulenova; Kalacheva; Potkina, A. Yu.
Russian Journal of General Chemistry, 2011 , vol. 81, # 3 p. 550 - 558
反应条件
sodium hydride in toluene
Reflux;
参考文献
Jiang, Yan; Chen, Xing; Zheng, Yongsheng; Xue, Zhouyang; Shu, Chang; Yuan, Weicheng; Zhang, Xiaomei
Angewandte Chemie - International Edition, 2011 , vol. 50, # 32 p. 7304 - 7307
反应条件
1,1'-carbonyldiimidazole
1.) THF, rt, 1 h; 2.) -78 degC, 1 h; Yield given. Multistep reaction;
参考文献
Hoffman, Robert V.; Saenz, James E.
Tetrahedron Letters, 1997 , vol. 38, # 49 p. 8469 - 8472
反应条件
lithium diisopropyl amide
1.) hexane, THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Ozawa, Naganori; Nakajima, Setsuko; Zaoya, Kyoko; Hamaguchi, Fumiko; Nagasaka, Tatsuo
Heterocycles, 1991 , vol. 32, # 5 p. 889 - 894
反应条件
(i) iPrMgCl, (ii) /BRN= 1072099/; Multistep reaction;
参考文献
Dubois,J.-E. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 791 - 797
反应条件
(i) iPrMgCl, (ii) /BRN= 1908172/; Multistep reaction;
参考文献
Dubois,J.E. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 1491 - 1496
