2-氰基-2-环己烷亚基乙酸甲酯合成路线 （共 7 条）
反应条件
in methanol; water T=80 - 90°C; Reflux; ConcentrationTimeTemperature;
参考文献
HIKAL LIMITED; YERANDE, Swapnil, Gulabrao; THAKUR, Rajesh, Mataprasad; SHARMA, Sundarakrishna, S.; GANGOPADHYAY, Ashok, Kumar; RUPP, Helmut; KUBAVAT, Hitesh; NAGARAJAN, Kuppuswamy; SELVAN, Arul; NUNNA, Rambabu; JALAJAKSHI, Vivekananda, Induharappa
Patent: WO2013/190357 A1, 2013 ;
Location in patent: Page/Page column 16-17 ;
反应条件
ammonium chloride in water; N,N-dimethyl-formamide T=100°C; 12 h;
参考文献
Picard, Philippe; Moulines, Jean; Lecoustre, Max
Bulletin de la Societe Chimique de France, 1984 , vol. 2, # 1-2 p. 65 - 70
反应条件
1.1: water; methanol / 80 - 90 °C / |Reflux 2.1: sodium hydrogencarbonate / aq. buffer / 28 h / 25 °C / pH 7.4 - 7.5 / |Enzymatic reaction 2.2: 20 °C 2.3: Raney Nickel / 80 °C / 7500.75 Torr / |Inert atmosphere View Scheme
参考文献
HIKAL LIMITED; YERANDE, Swapnil, Gulabrao; THAKUR, Rajesh, Mataprasad; SHARMA, Sundarakrishna, S.; GANGOPADHYAY, Ashok, Kumar; RUPP, Helmut; KUBAVAT, Hitesh; NAGARAJAN, Kuppuswamy; SELVAN, Arul; NUNNA, Rambabu; JALAJAKSHI, Vivekananda, Induharappa
Patent: WO2013/190357 A1, 2013 ;
反应条件
1.1: water; methanol / 80 - 90 °C / |Reflux 2.1: water; ammonia; hydrogenchloride / 25 - 35 °C / pH 7.4 / |Enzymatic reaction 2.2: Raney Nickel / 8 h / 50 - 60 °C / 7500.75 Torr View Scheme
反应条件
1: water; methanol / 80 - 90 °C / |Reflux 2: sodium hydrogencarbonate; water / aq. buffer / 24 h / 20 - 35 °C / pH 7.5 / |Enzymatic reaction View Scheme
参考文献
HIKAL LIMITED; YERANDE, Swapnil, Gulabrao; THAKUR, Rajesh, Mataprasad; SHARMA, Sundarakrishna, S.; GANGOPADHYAY, Ashok, Kumar; RUPP, Helmut; KUBAVAT, Hitesh; NAGARAJAN, Kuppuswamy; SELVAN, Arul; NUNNA, Rambabu; JALAJAKSHI, Vivekananda, Induharappa
Patent: WO2013/190357 A1, 2013 ;
反应条件
ammonium acetate in cyclohexane; water
T=75 - 80°C; 7.5 h; Dean-Stark; Reagent/catalystTimeTemperatureSolvent;
参考文献
HIKAL LIMITED; YERANDE, Swapnil, Gulabrao; THAKUR, Rajesh, Mataprasad; SHARMA, Sundarakrishna, S.; GANGOPADHYAY, Ashok, Kumar; RUPP, Helmut; KUBAVAT, Hitesh; NAGARAJAN, Kuppuswamy; SELVAN, Arul; NUNNA, Rambabu; JALAJAKSHI, Vivekananda, Induharappa
Patent: WO2013/190357 A1, 2013 ;
Location in patent: Page/Page column 14-15 ;
反应条件
1: cyclohexanone; Wang-resin-OCOCH2CN With dihydridotetrakis(triphenylphosphine)ruthenium(II) in tetrahydrofuran
T=60°C; Michael reaction; 30 h;
2: methanol With triethylamine in N,N-dimethyl-formamide
参考文献
Takaya; Murahashi
Synlett, 2001 , # SPEC. ISS p. 991 - 994
