2-氯-3-硝基-6-甲基吡啶合成路线 （共 22 条）
反应条件
in N,N-dimethyl-formamide 6 h; Heating;
参考文献
Troschutz; Karger
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1815 - 1821
反应条件
1: copper-powder; benzoic acid / 150 °C 2: KMnO4; H2O View Scheme
参考文献
Brown
Journal of the American Chemical Society, 1954 , vol. 76, p. 3167
反应条件
1: in tetrahydrofuran T=-78 - 20°C; 18 h; 2: With water; ammonium chloride in tetrahydrofuran
参考文献
Kuehne, Holger; Luebbers, Thomas; Mattei, Patrizio; Maugeais, Cyrille; Pflieger, Philippe; Scalone, Michelangelo
Patent: US2007/185154 A1, 2007 ;
Location in patent: Page/Page column 9 ;
反应条件
1: 80.5 percent / hydrazine hydrate / Raney nickel / ethanol / 70 deg C, 10 min; room temperature, 0.5 h 2: 67.5 percent / aq. NaNO2, CuCl, HCl / 0.17 h / 50 °C View Scheme
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
反应条件
1: 85 percent / Et3N; ZnCl2 / tetrahydrofuran / 20 °C 2: 78 percent / H2 / 10percent Pd/C / methanol / 20 °C / 3102.97 Torr View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
sodium dichromate; sulfuric acid T=30°C; 40 h;
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
Location in patent: Page/Page column 12 ;
反应条件
tetrakis (triphenylphosphine) palladium (0) in tetrahydrofuran; dichloromethane
参考文献
Bristol-Myers Squibb Company
Patent: US6011029 A1, 2000 ;
反应条件
triethylamine; zinc(II) chloride in tetrahydrofuran T=20°C;
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
copper; benzoic acid T=150°C;
参考文献
Brown
Journal of the American Chemical Society, 1954 , vol. 76, p. 3167
反应条件
formic acid; sodium iodide
参考文献
Baumgarten et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 596,598
