2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
(2-mesityl-1H-inden-3-yl)dicyclohexylphosphine; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate in ethylene glycol dimethyl ether
T=120°C; Buchwald-Hartwig amination; 24 h; Inert atmosphere;
参考文献
Hao, Xiaowei; Yuan, Jia; Yu, Guang-Ao; Qiu, Ming-Qiang; She, Neng-Fang; Sun, Yue; Zhao, Cui; Mao, Shu-Lan; Yin, Jun; Liu, Sheng-Hua
Journal of Organometallic Chemistry, 2012 , vol. 706-707, p. 99 - 105
反应条件
2: (decarboxylation)
View Scheme
参考文献
Itier,J.; Casadevall,A.
Bulletin de la Societe Chimique de France, 1969 , p. 2342 - 2355
反应条件
magnesium
1) THF; 2) 0 grad C, 0.5 h; Yield given. Multistep reaction;
参考文献
Freeman, Sally; Harger, Martin J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1399 - 1406
反应条件
pyrrolidine; triphenylphosphine; 1-n-butyl-3-methylimidazolium tetrafluoroborate; bis(η3-allyl-μ-chloropalladium(II))
T=130°C; Heck alkynylation; 48 h;
参考文献
Hierso, Jean-Cyrille; Picquet, Michel; Cattey, Helene; Meunier, Philippe
Synlett, 2006 , # 18 p. 3005 - 3008
反应条件
potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); 2-(di-1-adamantylphosphanyl)-1-(2,6-diisopropylphenyl)-1H-imidazole in 1,4-dioxane; water
T=100°C; 20 h;
参考文献
Schulz, Thomas; Torborg, Christian; Schaeffner, Benjamin; Huang, Jun; Zapf, Alexander; Kadyrov, Renat; Boerner, Armin; Beller, Matthias
Angewandte Chemie - International Edition, 2009 , vol. 48, # 5 p. 918 - 921
反应条件
copper(l) chloride; palladium dichloride; tris(p-fluoro phenyl)phosphine in N,N-dimethyl-formamide
T=100°C; sila-Sonogashira-Hagihara cross-coupling; 12 h; Inert atmosphere;
参考文献
Nishihara, Yasushi; Inoue, Eiji; Noyori, Shintaro; Ogawa, Daisuke; Okada, Yoshiaki; Iwasaki, Masayuki; Takagi, Kentaro
Tetrahedron, 2012 , vol. 68, # 24 p. 4869 - 4881
反应条件
tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine; tetrabutyl ammonium fluoride in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=90°C; 12 h;
参考文献
Moon, Jeongju; Jang, Mihee; Lee, Sunwoo
Journal of Organic Chemistry, 2009 , vol. 74, # 3 p. 1403 - 1406
反应条件
1: iodobenzene; acetylenecarboxylic acid With 1-methyl-pyrrolidin-2-one; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride
T=20°C; Sonogashira coupling; 12 h;
2: 2-Bromo-1,3,5-trimethyl-benzene T=90°C; 12 h;
参考文献
Moon, Jeongju; Jeong, Miso; Nam, Hyungoog; Ju, Jinhun; Moon, Joong Ho; Jung, Hyun Min; Lee, Sunwoo
Organic Letters, 2008 , vol. 10, # 5 p. 945 - 948
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With magnesium
2: oxirane
参考文献
Wessig, Pablo; Teubner, Janek
Synlett, 2006 , # 10 p. 1543 - 1546
反应条件
1: 1) t-BuLi, 2) tellurium, 3) K3Fe(CN)6
2: copper / toluene / Heating
View Scheme
参考文献
Akiba, Mitsuo; Lakshmikantham, M. V.; Jen, Kwan-Yue; Cava, Michael P.
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4819 - 4821
