反应条件
1.1: Mg; 1,2-dibromoethane / diethyl ether / Heating
1.2: 20 percent / diethyl ether / 0.5 h / -20 - -15 °C
2.1: 6N aq. HCl / 5 h / Heating
3.1: oxalyl chloride / CH2Cl2 / 2 h / 20 °C
4.1: n-butyllithium / diethyl ether; hexane / 0 °C
4.2: 36 percent / diethyl ether; hexane / 20 °C
5.1: 6N aq. HCl / 24 h / Heating
6.1: HCl / 20 °C
View Scheme
参考文献
Tamiz, Amir P.; Zhang, Jianrong; Flippen-Anderson, Judith L.; Zhang, Mei; Johnson, Kenneth M.; Deschaux, Olivier; Tella, Srihari; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 6 p. 1215 - 1222
