1: With sulfuric acid in water
T=20°C; 0.166667 h; Inert atmosphere;
2: With (NH4)2S2O8; silver nitrate
T=90°C; 2 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HUBY, Nicholas John Silvester; LOPEZ-TAPIA, Francisco Javier; SO, Sung-Sau
Patent: WO2014/90715 A1, 2014 ;
Location in patent: Page/Page column 45 ;
Meyer,H.; Graf
Chemische Berichte, 1928 , vol. 61, # 2203 p. 2210
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Spaeth; Spitzer
Chemische Berichte, 1926 , vol. 59, p. 1479,1482
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Meyer,H.
Monatshefte fuer Chemie, 1901 , vol. 22, p. 116
1.1: 85 percent / Et3N; 1,3-dichlorocyclohexylcarbodiimide / CH2Cl2 / 20 °C
2.1: Mg / tetrahydrofuran / 1 h / 20 °C
2.2: 77 percent / tetrahydrofuran / -78 - 20 °C
3.1: Amberlyst 15; H2O / acetone / 4 h / 20 °C
3.2: 81 percent / Et3N / CH2Cl2 / 2 h / 20 °C
4.1: sodium triacetoxyborohydride; AcOH / CH2Cl2; tetrahydrofuran / -78 - 20 °C
4.2: Amberlyst 15 / CH2Cl2; tetrahydrofuran / 1 h / 20 °C
4.3: 84 percent / Et3N / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
