(R)-(-)-2-辛醇合成路线 （共 140 条）
反应条件
1: With (-)-(S)-[2-(2-methoxynaphthalen-1yl)phenyl]diphenylphosphine; trichlorosilane; bis(η3-allyl-μ-chloropalladium(II)) T=40°C; 24 h; 2: With potassium fluoride; potassium hydrogencarbonate in tetrahydrofuran; methanol T=20°C; 0.333333 h; 3: With dihydrogen peroxide in tetrahydrofuran; methanol T=20°C; 12 h; Title compound not separated from byproducts;
参考文献
Chemistry - A European Journal, , vol. 13, # 4 p. 1117 - 1128
反应条件
1: With potassium fluoride; potassium hydrogencarbonate in tetrahydrofuran; methanol T=0 - 20°C; 2 h; 2: With dihydrogen peroxide in tetrahydrofuran; methanol; water Product distribution / selectivity;
参考文献
US2008/139822 A1, ;
Page/Page column 17-18 ;
反应条件
1: With [RuCl2(p-cumene)]2; trifuran-2-yl-phosphane; sodium carbonate in toluene T=50°C; Schlenk techniqueInert atmosphere; 2: With bis(norbornadiene)rhodium(I) tetrafluoroborate; C46H35NO2P2; hydrogen in tetrahydrofuran T=20°C; P=15001.5 Torr; 1 h; Schlenk techniqueInert atmosphereAutoclave; 3: With sodium hydroxide in methanol T=20°C; 2 h; Schlenk techniqueInert atmosphere; Overall yield = 68 percent; Overall yield = 145.4 mg; enantioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 19, # 40 p. 13299 - 13303
反应条件
1: 90 percent / Amberlyst A-26 NO3(1-) form / toluene / 3 h / Heating 2: H2 / Pd/C / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 26, # 28 p. 3369 - 3372
参考文献
Journal of the American Chemical Society, , vol. 52, p. 3337
Journal of the American Chemical Society, , vol. 69, p. 309
反应条件
hydrogen; palladium on activated charcoal in methanol Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 26, # 28 p. 3369 - 3372
反应条件
molecular sieve; lipase B from Candida antarctica in 1,4-dioxane T=30°C; aminolysis; Enzymatic reaction;
参考文献
Tetrahedron Asymmetry, , vol. 11, # 7 p. 1459 - 1463
反应条件
whole cells of Rhodococcus ruber DSM 44541; acetone in phosphate buffer T=24°C; Oppenauer oxidation; pH=8.0; 24 h;
参考文献
Angewandte Chemie (International ed. in English), , vol. 41, # 6 p. 1014 - 1017
反应条件
phosphate buffer; immobilized lipase PS in methanol T=30°C; pH=7.0;
参考文献
Bioscience, Biotechnology and Biochemistry, , vol. 67, # 1 p. 203 - 206
反应条件
(R)-2-(piperidin-1-yl)-1,1,2-triphenylethanol in hexane T=22°C; 36 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 13 p. 2085 - 2090
