反应条件
1.1: aq. HNO3; KNO3 / 1.67 h / 0 °C
1.2: 69 percent / CuCN; aq. KOH / H2O / 0.5 h / 62 - 70 °C
2.1: DIBAL / tetrahydrofuran; hexane / 22.5 h / 0 - 20 °C
3.1: 14.0 g / NaBH4 / tetrahydrofuran / 3.83 h / 0 - 20 °C
4.1: Et3N / tetrahydrofuran / 1.83 h / 0 - 20 °C
5.1: dimethylformamide; H2O / 3.5 h / 20 °C
View Scheme
参考文献
Plouvier, Bertrand; Beatch, Gregory N.; Jung, Grace L.; Zolotoy, Alexander; Sheng, Tao; Clohs, Lilian; Barrett, Terrance D.; Fedida, David; Wang, Wei Q.; Zhu, Jeff J.; Liu, Yuzhong; Abraham, Shlomo; Lynn, Leah; Dong, Ying; Wall, Richard A.; Walker, Michael J. A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 12 p. 2818 - 2841