1,3-二氨基-2-羟基丙烷合成路线 （共 34 条）
反应条件
sodium hydroxide in water Heating;
参考文献
Feig, Andrew L.; Lippard, Stephen J.
Journal of the American Chemical Society, 1994 , vol. 116, # 18 p. 8410 - 8411
反应条件
in acetonitrile 2 h; Ambient temperature;
参考文献
Kinney, William A.; Abou-Gharbia, Magid; Garrison, Deanna T.; Schmid, Jean; Kowal, Dianne M.; Bramlett, Donna R.; Miller, Tracy L.; Tasse, Rene P.; Zaleska, Margaret M.; Moyer, John A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 2 p. 236 - 246
反应条件
in dichloromethane 3 h;
参考文献
SCHERING CORPORATION
Patent: WO2006/19768 A1, 2006 ;
Location in patent: Page/Page column 107-108 ;
WO 2006/019768 A1
反应条件
in ethanol
10 h; Reflux;
参考文献
Biswas, Bhaskar; Mitra, Merry; Adhikary, Jaydeep; Rama Krishna; Bag, Partha Pratim; Reddy, C. Malla; Aliaga-Alcalde, Nuria; Chattopadhyay, Tanmay; Das, Debasis; Ghosh, Rajarshi
Polyhedron, 2013 , vol. 53, p. 264 - 268
反应条件
in ethanol
Condensation;
参考文献
Zeyrek; Elmali; Elerman
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 8 p. 898 - 902
反应条件
in methanol
2 h; Reflux;
参考文献
Locke, Julie M.; Griffith, Renate; Bailey, Trevor D.; Crumbie, Robyn L.
Tetrahedron, 2009 , vol. 65, # 51 p. 10685 - 10692
反应条件
in ethanol
2 h; Heating;
参考文献
Nishida, Yuzo; Kida, Sigeo
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1986 , p. 2633 - 2640
反应条件
in ethanol
1 h; Heating;
参考文献
Foks, Henryk; Pancechowska-Ksepko, Danuta; Janowiec, Mieczyslaw; Zwolska, Zofia; Augustynowicz-Kopec, Ewa
Phosphorus, Sulfur and Silicon and the Related Elements, 2005 , vol. 180, # 10 p. 2291 - 2297
参考文献
Mallinckrodt Medical Inc.
Patent: US5405601 A1, 1995 ;
反应条件
1: 1,3-Diamino-2-hydroxypropane With sodium hydride in N,N-dimethyl acetamide
2: 2,4-dichloro-1-fluorobenzene in N,N-dimethyl acetamide
T=170°C; 0.0694444 h; microwave irradiation;
参考文献
Sandin, Helena; Swanstein, Marie-Louise; Wellner, Eric
Journal of Organic Chemistry, 2004 , vol. 69, # 5 p. 1571 - 1580
