1: trans-cyclooctene With ozone in methanol; dichloromethane T=-70°C; 8 h; 2: With toluene-4-sulfonic acid in methanol; dichloromethane T=-70°C; 6 h; 3: dimethoxy sulfoxide With sodium hydrogencarbonate more than 3 stages;
参考文献
Theravance, Inc.
Patent: US2005/277688 A1, 2005 ;
Location in patent: Page/Page column 12 ;
US 20050277688 A1
1: methanol; cyclooctene With ozone in dichloromethane T=-70°C; 8 h; 2: With toluene-4-sulfonic acid in dichloromethane T=-70°C; 6 h; 3: dimethoxy sulfoxide With sodium hydrogencarbonate more than 3 stages;
