(S)-(+)-2-辛醇合成路线 （共 200 条）
反应条件
alcohol dehydrogenase from Lactobacillus kefir; alcohol dehydrogenase from Rhodococcus ruber DSM 44541; YcnD-oxidoreductase T=30°C; pH=7.5; 3 h; aq. bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantiospecific reaction;
参考文献
Voss, Constance V.; Gruber, Christian C.; Faber, Kurt; Knaus, Tanja; Macheroux, Peter; Kroutil, Wolfgang
Journal of the American Chemical Society, 2008 , vol. 130, # 42 p. 13969 - 13972
反应条件
1.1: pyridine / CH2Cl2 / 0.17 h / 20 °C 1.2: 100 percent / CH2Cl2 / 2.5 h / 20 °C 2.1: 46 percent / aq. H2SO4 / tetrahydrofuran / 19 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 59, # 34 p. 6647 - 6658
反应条件
Novozyme 435 in neat (no solvent) T=45°C; P=760.051 Torr; 12 h; Molecular sieveGreen chemistryEnzymatic reaction; enantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 24, # 5-6 p. 249 - 253
反应条件
Novozyme 435 in neat (no solvent) T=45°C; P=760.051 Torr; 12 h; Molecular sieveGreen chemistryEnzymatic reaction; enantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 24, # 5-6 p. 249 - 253
反应条件
1: With His-tagged Pseudomonas sp. metallo-β-lactamase-type alkylsulfatase Pisa1; water; tris(hydroxymethyl)methylamine hydrochloride T=30°C; pH=8.2; 24 h; Resolution of racemateEnzymatic reaction; 2: With water; toluene-4-sulfonic acid in 1,4-dioxane; tert-butyl methyl ether T=40°C; 5 h; optical yield given as percent eestereoselective reaction;
参考文献
Schober, Markus; Gadler, Petra; Knaus, Tanja; Kayer, Heidemarie; Birner-Gruenberger, Ruth; Guelly, Christian; MacHeroux, Peter; Wagner, Ulrike; Faber, Kurt
Organic Letters, 2011 , vol. 13, # 16 p. 4296 - 4299
反应条件
Novozyme 435 in neat (no solvent) T=45°C; P=760.051 Torr; 16 h; Molecular sieveGreen chemistryEnzymatic reaction; enantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 24, # 5-6 p. 249 - 253
反应条件
methanesulfonic acid; (R,R)-dihydroborate in hexane T=-20°C; 48 h; Title compound not separated from byproducts;
参考文献
Imai, Toshiro; Tamura, Tadashi; Yamamuro, Akira; Sato, Tsuneo; Wollmann, Theodor A.; et al.
Journal of the American Chemical Society, 1986 , vol. 108, # 23 p. 7402 - 7404
反应条件
[(R)-1,1'-binaphthyl-2,2'-diyldioxy]{bis[(S)-(1-phenylethyl)]amino}phosphine; bis(acetylacetonate)nickel(II) in tetrahydrofuran; hexane T=-20°C; 6 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 44, # 15 p. 2232 - 2234
反应条件
1: dimethyl zinc With C32H34N4NiO2 in toluene T=0 - 20°C; 0.5 h; Inert atmosphereSchlenk technique; 2: hexanal in toluene T=20°C; 8 h; Schlenk techniqueInert atmosphere; enantioselective reaction;
参考文献
Tetrahedron, , vol. 69, # 2 p. 551 - 558
反应条件
1: With hydrogen; [Ru{(S)-MeO-BIPHEP}Br2] in methanol T=25°C; Hydrogenation; P=37503.8 Torr; 2: With nickel desulfurization; Further stages. Title compound not separated from byproducts.;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1535 - 1537
