1: 84 percent / aq. sodium carbonate; CuI / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 1 h / 90 °C
2: 97 percent / H2 / Pd/C / methanol / 24 h
3: 68 percent / TFA / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Yano, Jason K.; Denton, Travis T.; Cerny, Matthew A.; Zhang, Xiaodong; Johnson, Eric F.; Cashman, John R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 6987 - 7001