4-溴-N,N-二甲基苄胺合成路线 （共 25 条）
反应条件
potassium carbonate in tetrahydrofuran T=60°C; 24 h;
参考文献
Kawagoe, Yuhsuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2013 , vol. 69, # 19 p. 3971 - 3977
反应条件
pentacarbonyliron(0); 1,1,3,3-tetramethyldisiloxane in toluene T=100°C; 25.5 h; Inert atmosphere;
参考文献
Sunada, Yusuke; Kawakami, Hiroko; Imaoka, Tsuyoshi; Motoyama, Yukihiro; Nagashima, Hideo
Angewandte Chemie - International Edition, 2009 , vol. 48, # 50 p. 9511 - 9514
反应条件
1: With titanium(IV) isopropylate in methanol T=20°C; Addition; 2: With sodium tetrahydroborate in methanol T=20°C; Reduction; 1.5 h;
参考文献
Bhattacharyya, Sukanta
Synthetic Communications, 2000 , vol. 30, # 11 p. 2001 - 2008
反应条件
dimethyl amine in benzene
参考文献
US4496567 A1, ;
US 4496567 A
反应条件
1: With titanium(IV) isopropylate; triethylamine in ethanol T=25°C; 12 h; 2: With sodium tetrahydroborate in ethanol T=25°C; 12 h;
参考文献
Feng, Ruokun; Yao, Jinzhong; Liang, Zunjun; Liu, Zhanxiang; Zhang, Yuhong
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 3688 - 3696
反应条件
1: methyl 3-(dimethylamino)-propanoate With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-30°C; Inert atmosphere; 2: 4-bromo-benzyl bromide in tetrahydrofuran; n-heptane; ethylbenzene T=-30 - -15°C; Inert atmosphere;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 52, # 1 p. 23 - 28
反应条件
iodosylbenzene; 5,10,15,20-tetrakisphenylporphyrinatoiron(III) chloride in benzene
参考文献
Smith, John R. Lindsay; Mortimer, David N.
Journal of the Chemical Society, Chemical Communications, 1985 , # 2 p. 64 - 65
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=0°C; Flow reactor; 2: With 2-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide in tetrahydrofuran; hexane T=0°C; Flow reactor; Reagent/catalyst;
参考文献
Chemistry - An Asian Journal, , vol. 8, # 4 p. 705 - 708
反应条件
1: 1-(4-bromophenyl)-N,N-dimethylmethanamine With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: tributoxyborane in tetrahydrofuran T=-78 - 0°C; 1 h; 3: With water in tetrahydrofuran T=0°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/18941 A2, 2007 ;
Location in patent: Page/Page column 58 ;
WO 2007/018941 A2
反应条件
iodosylbenzene; 5,10,15,20-tetrakisphenylporphyrinatoiron(III) chloride in benzene
参考文献
Smith, John R. Lindsay; Mortimer, David N.
Journal of the Chemical Society, Chemical Communications, 1985 , # 2 p. 64 - 65
