5,6-二甲氧基吲哚啉-2-酮合成路线 （共 16 条）
参考文献
Flood; Nieuwland
Journal of the American Chemical Society, 1928 , vol. 50, p. 2570
参考文献
Sircar
Journal of the Chemical Society, 1928 , p. 56
参考文献
Engfeldt
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1921 , vol. 112, p. 182,184
参考文献
Claus; Wollner
Chemische Berichte, 1885 , vol. 18, p. 1858,1859
参考文献
Claus; Wollner
Chemische Berichte, 1885 , vol. 18, p. 1858,1859
反应条件
iron; acetic acid
T=20°C; 1 h; Heating / reflux;
参考文献
Cell Therapeutics Europe S.r.I
Patent: US2005/209195 A1, 2005 ;
Location in patent: Page/Page column 6-7 ;
US 20050209195 A1
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Kawase, Masami; Kitamura, Takahiro; Kikugawa, Yasuo
Journal of Organic Chemistry, 1989 , vol. 54, # 14 p. 3394 - 3403
反应条件
1: 80 percent / triethylamine, 1,3-dicyclohexylcarbodiimide / CH2Cl2 / 16 h / Ambient temperature
2: tert-butyl hypochlorite / diethyl ether / 0.33 h / 0 °C
3: 73 percent / Ag2CO3, trifluoroacetic acid / 0.5 h / 0 °C
4: 88 percent / H2 / 10percent Pd/C / methanol
View Scheme
参考文献
Kawase, Masami; Kitamura, Takahiro; Kikugawa, Yasuo
Journal of Organic Chemistry, 1989 , vol. 54, # 14 p. 3394 - 3403
反应条件
1: tert-butyl hypochlorite / diethyl ether / 0.33 h / 0 °C
2: 73 percent / Ag2CO3, trifluoroacetic acid / 0.5 h / 0 °C
3: 88 percent / H2 / 10percent Pd/C / methanol
View Scheme
参考文献
Kawase, Masami; Kitamura, Takahiro; Kikugawa, Yasuo
Journal of Organic Chemistry, 1989 , vol. 54, # 14 p. 3394 - 3403
反应条件
palladium; acetic acid
Hydrogenation;
参考文献
Walker
Journal of the American Chemical Society, 1955 , vol. 77, p. 3844,3848,6729
