1: With 1,3-Dithiane; n-butyllithium in tetrahydrofuran; cyclohexane
T=-30 - -15°C; 2 h;
2: 5-fluoroindan-1-one in tetrahydrofuran
T=0°C; 22 h;
3: acetic acid With hydrogenchloride; toluene-4-sulfonic acid
more than 3 stages;
参考文献
ALLERGAN, INC.
Patent: WO2003/99795 A1, 2003 ;
Location in patent: Page 136 - 141 ;
WO 03/099795 A1