(1,3-二噻烷-2-基)膦酸二乙酯合成路线 （共 10 条）
反应条件
1.1: LDA / hexane; tetrahydrofuran / 0.08 h / -78 °C 1.2: 76 percent / hexane; tetrahydrofuran / -78 - 20 °C 2.1: 79 percent / aq. AgNO3; Br2 / acetonitrile / 0 - 20 °C View Scheme
参考文献
Afarinkia, Kamyar; Faller, Andrew; Twist, Andrew J.
Synthesis, 2003 , # 3 p. 357 - 360
反应条件
1.1: LDA / hexane; tetrahydrofuran / 0.08 h / -78 °C 1.2: 78 percent / hexane; tetrahydrofuran / -78 - 20 °C 2.1: 78 percent / aq. AgNO3; Br2 / acetonitrile / 0 - 20 °C View Scheme
参考文献
Afarinkia, Kamyar; Faller, Andrew; Twist, Andrew J.
Synthesis, 2003 , # 3 p. 357 - 360
反应条件
titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; alpha,alpha-dimethylbenzyl hydroperoxide in dichloromethane Oxidation;
参考文献
Aggarwal, Varinder K.; Barrell, Juliet K.; Worrall, Julia M.; Alexander, Rikki
Phosphorus, Sulfur and Silicon and Related Elements, 1999 , vol. 153-154, p. 337 - 338
反应条件
titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; alpha,alpha-dimethylbenzyl hydroperoxide in dichloromethane
参考文献
Aggarwal, Varinder K.; Worrall, Julia M.; Alexander, Rikki
Phosphorus, Sulfur and Silicon and Related Elements, 1997 , vol. 120-121, p. 351 - 352
反应条件
n-butyllithium 1.) THF, n-hexane, -78 deg C, 10 min, 2.) THF, -60 deg C, 20 min; Yield given. Multistep reaction;
参考文献
Mikolajczyk, Marian; Balczewski, Piotr
Tetrahedron, 1992 , vol. 48, # 40 p. 8697 - 8710
反应条件
1.1: LDA / hexane; tetrahydrofuran / 0.08 h / -78 °C 1.2: 74 percent / hexane; tetrahydrofuran / -78 - 20 °C 2.1: 80 percent / aq. AgNO3; Br2 / acetonitrile / 0 - 20 °C View Scheme
参考文献
Afarinkia, Kamyar; Faller, Andrew; Twist, Andrew J.
Synthesis, 2003 , # 3 p. 357 - 360
反应条件
1: 1,3-Dithiane With N-chloro-succinimide in benzene
T=20°C; 24 h;
2: triethyl phosphite in benzene
T=60°C; 4 h; Further stages.;
参考文献
Aggarwal, Varinder K.; Roseblade, Stephen J.; Barrell, Juliet K.; Alexander, Rikki
Organic Letters, 2002 , vol. 4, # 7 p. 1227 - 1229
反应条件
1: 1,3-Dithiane With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78°C; 0.5 h;
2: diethyl chlorophosphate in tetrahydrofuran
T=-78°C; 1 h; Further stages.;
参考文献
Liu, Bin; Duan, Shengquan; Sutterer, Angela C.; Moeller, Kevin D.
Journal of the American Chemical Society, 2002 , vol. 124, # 34 p. 10101 - 10111
反应条件
in benzene
T=60°C; 4 h;
参考文献
Afarinkia, Kamyar; Faller, Andrew; Twist, Andrew J.
Synthesis, 2003 , # 3 p. 357 - 360
反应条件
water in tetrahydrofuran
Ambient temperature;
参考文献
Iorga, Bogdan; Mouries, Virginie; Savignac, Philippe
Bulletin de la Societe Chimique de France, 1997 , vol. 134, # 10,11 p. 891 - 896
