5-叔丁氧基-5-氧代戊酸合成路线 （共 10 条）
反应条件
1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 2 h;
参考文献
WISCONSIN ALUMNI RESEARCH FOUNDATION
Patent: WO2007/112358 A1, 2007 ;
Location in patent: Page/Page column 51-52 ;
参考文献
Homan
Recueil des Travaux Chimiques des Pays-Bas, 1944 , vol. 63, p. 189
反应条件
4-(N,N-dimethlyamino)pyridine; 1-hydroxy-pyrrolidine-2,5-dione; triethylamine in toluene
T=115°C; 16 h;
参考文献
WISCONSIN ALUMNI RESEARCH FOUNDATION
Patent: WO2007/112358 A1, 2007 ;
Location in patent: Page/Page column 51 ;
反应条件
1: With methanol; lithium hydroxide; water
T=0°C; 4 h;
2: With hydrogenchloride in water
pH=6.8;
3: With citric acid in water
T=0°C; pH=3.8;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2006/100158 A1, 2006 ;
Location in patent: Page/Page column 31 ;
反应条件
zinc(II) chloride
T=60°C; 72 h;
参考文献
Bitan, Gal; Muller, Dan; Kasher, Ron; Gluhov, Evgenia V.; Gilon, Chaim
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 10 p. 1501 - 1510
反应条件
potassium tert-butylate in tetrahydrofuran; water; ethyl acetate
参考文献
Fujisawa Pharmaceutical Company, Ltd.
Patent: US4349552 A1, 1982 ;
反应条件
sodium tetrahydroborate; azobisisobutyronitrile; tributyltin chloride in ethanol
7 h; Ambient temperature;
参考文献
Foubelo, Francisco; Lloret, Francisco; Yus, Miguel
Tetrahedron, 1993 , vol. 49, # 37 p. 8465 - 8470
反应条件
bis(acetylacetonate)oxovanadium in benzene
T=20°C;
参考文献
Stepovik; Gulenova; Kalacheva; Potkina, A. Yu.
Russian Journal of General Chemistry, 2011 , vol. 81, # 3 p. 550 - 558
反应条件
(i) POCl3, Py, (ii) aq. NaOH, dioxane; Multistep reaction;
参考文献
Geiger; Sandow
Justus Liebigs Annalen der Chemie, 1977 , vol. No.6, p. 897 - 903
参考文献
Homan
Recueil des Travaux Chimiques des Pays-Bas, 1944 , vol. 63, p. 189
