3,3'-亚戊烯基-4-丁内酰胺合成路线 （共 23 条）
反应条件
methanol; tert-butylhypochlorite; potassium tert-butylate; potassium bromide T=60°C; Hofmann type rearrangement; 24 h; Inert atmosphere;
参考文献
Moriyama, Katsuhiko; Ishida, Kazuma; Togo, Hideo
Chemical Communications, 2012 , vol. 48, # 68 p. 8574 - 8576
反应条件
1.1: toluene / 1 h / 0 - 20 °C 1.2: 798 mg / triethylamine / toluene / 2 h / 0 - 20 °C 2.1: 26 percent / tributyltin hydride 3.1: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 4.1: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 33 p. 6221 - 6231
反应条件
1.1: toluene / Heating 2.1: toluene / 1 h / 0 - 20 °C 2.2: 798 mg / triethylamine / toluene / 2 h / 0 - 20 °C 3.1: 26 percent / tributyltin hydride 4.1: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 5.1: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 33 p. 6221 - 6231
反应条件
1: 26 percent / tributyltin hydride 2: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 3: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 33 p. 6221 - 6231
反应条件
1.1: ammonium acetate / methanol / 65 - 95 °C 2.1: sodium hydrogencarbonate / aq. buffer / 28 h / 25 °C / pH 7.4 - 7.5 / |Enzymatic reaction 2.2: 20 °C 2.3: Raney Nickel / 80 °C / 7500.75 Torr / |Inert atmosphere View Scheme
反应条件
1.1: CH2Cl2 / 20 °C 2.1: DMAB; methanesulfonic acid / diethyl ether / 3 h / 0 °C 2.2: 81 percent / pyridine / CH2Cl2 / 0 °C 3.1: 77 percent / CuCl; TMEDA / acetonitrile / 20 h / 60 °C 4.1: 90 percent / Raney-Ni / ethanol / 21 h / 110 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 50 p. 9951 - 9960
反应条件
1: 77 percent / CuCl; TMEDA / acetonitrile / 20 h / 60 °C 2: 90 percent / Raney-Ni / ethanol / 21 h / 110 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 50 p. 9951 - 9960
反应条件
1: Raney nickel; water / ethanol / 110 °C 2: 39 mg / magnesium monoperoxyphthalate hexahydrate / methanol / 3 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 33 p. 6221 - 6231
反应条件
1: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 2: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 33 p. 6221 - 6231
反应条件
1: 68 mg / AIBN; tributyltin hydride; water / toluene / 0.75 h / Heating 2: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 3: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 33 p. 6221 - 6231
