4-(羟甲基)苯甲酸甲酯合成路线 （共 132 条）
反应条件
thionyl chloride T=20°C; 15 h;
参考文献
Okada, Yoshio; Tsuda, Yuko; Tada, Mayako; Wanaka, Keiko; Okamoto, Utako; Hijikata-Okunomiya, Akiko; Okamoto, Shosuke
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1964 - 1972
反应条件
1: trichloromonobromomethane With triphenylphosphine in dichloromethane T=20°C; Appel reaction; 0.666667 h; in air; 2: 4-hydroxymethyl-benzoic acid methylester in dichloromethane T=20°C; Appel reaction; in air;
参考文献
Newman, Stephen G.; Bryan, Christopher S.; Perez, Didier; Lautens, Mark
Synthesis, 2011 , # 2 art. no. Z27210SS, p. 342 - 346
反应条件
cadmium(II) sulphide in acetonitrile T=20°C; P=37.5038 Torr; 24 h; Inert atmosphereIrradiation;
参考文献
Mitkina, Tatiana; Stanglmair, Christoph; Setzer, Wolfgang; Gruber, Michael; Kisch, Horst; Koenig, Burkhard
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 17 p. 3556 - 3561
反应条件
1: 4-hydroxymethyl-benzoic acid methylester With ammonia; lithium; tert-butyl alcohol in tetrahydrofuran T=-65 - 15°C; Birch Reduction; 1 h; Inert atmosphere; 2: methyl iodide With ammonium chloride in tetrahydrofuran T=-65°C; Birch Reduction; 0.583333 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 78, # 1 p. 83 - 92
反应条件
bis(cyclopentadienyl)titanium dichloride; manganese in tetrahydrofuran 0.916667 h; Inert atmosphereReflux;
参考文献
Dieguez, Horacio R.; Lopez, Armando; Domingo, Victoriano; Arteaga, Jesus F.; Dobado, Jose A.; Herrador, M. Mar; Quilez Del Moral, Jose F.; Barrero, Alejandro F.
Journal of the American Chemical Society, 2010 , vol. 132, # 1 p. 254 - 259
反应条件
oxygen; palladium diacetate; sodium carbonate in cyclohexane T=130°C; 36 h; Molecular sieveSchlenk technique; SolventTime;
参考文献
Chemical Communications, , vol. 49, # 3 p. 252 - 254
反应条件
in toluene T=130°C; 24 h; Schlenk techniqueInert atmosphereSealed tube;
参考文献
Chen, Jing; Huang, Shijun; Lin, Jin; Su, Weiping
Applied Catalysis A: General, 2014 , vol. 470, p. 1 - 7
反应条件
N-phenyl-N,N-di(2-hydroxyethyl)amine; diethylzinc in toluene T=20°C; 24 h;
参考文献
Mino, Takashi; Hasegawa, Tae; Shirae, Yoshiaki; Sakamoto, Masami; Fujita, Tsutomu
Journal of Organometallic Chemistry, 2007 , vol. 692, # 20 p. 4389 - 4396
反应条件
triethylamine in 1,1-dimethylpropan-1-ol T=20°C; 12 h;
参考文献
Kuwano, Ryoichi; Yokogi, Masashi
Chemical Communications, 2005 , # 47 p. 5899 - 5901
反应条件
oxygen; sodium acetate; (neocuproine)Pd(OAc)2 in water; dimethyl sulfoxide T=80°C; P=22502.3 Torr; 4 h;
参考文献
Ten Brink, Gerd-Jan; Arends, Isabel W. C. E.; Hoogenraad, Marcel; Verspui, Goeran; Sheldon, Roger A.
Advanced Synthesis and Catalysis, 2003 , vol. 345, # 12 p. 1341 - 1352
