1-羟基环己烷丙酸 gamma-内酯合成路线 （共 73 条）
反应条件
1: 85 percent / hydroquinone / 4 h / 155 °C
2: 87 percent / H2 / 10percent Pd/C / 760 - 1520 Torr / Ambient temperature
View Scheme
参考文献
Alonso, Daniel; Font, Josep; Ortuno, Rosa M.
Journal of Organic Chemistry, 1991 , vol. 56, # 19 p. 5567 - 5572
反应条件
1: 80 percent / tetrahydrofuran
2: 81 percent / Jones reagent / acetone / 1 h / 0 °C
View Scheme
参考文献
Canonne, Persephone; Foscolos, Georges B.; Belanger, Denis
Journal of Organic Chemistry, 1980 , vol. 45, # 10 p. 1828 - 1835
反应条件
1: 25 percent / Zn
2: 77 percent / Zn dust, TMEDA, AcOH / ethyl acetate
3: MgBr2 / CH2Cl2
View Scheme
参考文献
Black, T. Howard; McDermott, Todd S.; Eisenbeis, Shane A.
Tetrahedron Letters, 1990 , vol. 31, # 46 p. 6617 - 6620
反应条件
1: potassium tert-butoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / 50 - 60 °C
2: 66 percent / pyridinium chlorochromate / CH2Cl2 / 1.5 h / 28 °C / celite
View Scheme
参考文献
Baskaran, Sundarababu; Islam, Imadul; Chandrasekaran, Srinivasan
Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 891 - 895
反应条件
samarium diiodide in tetrahydrofuran
T=20°C; Kagan-Molander Coupling;
参考文献
Sanai, Yasuyuki; Morita, Yuki; Asano, Youichi; Ishizaki, Kenichi; Kubota, Kouzou
Journal of Polymer Science, Part A: Polymer Chemistry, 2014 , vol. 52, # 8 p. 1161 - 1171
反应条件
in ethanol; sulfuric acid
T=30°C; electrochemical reaction: mercury pool cathode, platinum anode;
参考文献
Prasad; Misra
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 4 p. 392 - 393
反应条件
hydrogenchloride
1.) THF overnight, 2.) 40 deg C, 1h; Yield given. Multistep reaction;
参考文献
Canonne, Persephone; Belanger, Denis; Lemay, Gilles; Foscolos, Georges B.
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3091 - 3097
反应条件
1: 71 percent / pyridine / 24 h / 0 - 5 °C
2: 54 percent / NaI / acetone / 24 h / Heating
3: 94 percent / NaCN / 72 h / 80 °C
4: 59 percent / 96 percent H2SO4 / methanol / 24 h / Heating
View Scheme
参考文献
Crotti, Paolo; Badalassi, Fabrizio; Di Bussolo, Valeria; Favero, Lucilla; Pineschi, Mauro
Tetrahedron, 2001 , vol. 57, # 40 p. 8559 - 8572
反应条件
1: 62 percent / LiAlH4 / diethyl ether / 3 h / 0 - 20 °C
2: 71 percent / pyridine / 24 h / 0 - 5 °C
3: 54 percent / NaI / acetone / 24 h / Heating
4: 94 percent / NaCN / 72 h / 80 °C
5: 59 percent / 96 percent H2SO4 / methanol / 24 h / Heating
View Scheme
参考文献
Crotti, Paolo; Badalassi, Fabrizio; Di Bussolo, Valeria; Favero, Lucilla; Pineschi, Mauro
Tetrahedron, 2001 , vol. 57, # 40 p. 8559 - 8572
反应条件
1: 48 percent / Li; PrNH2
2: 71 percent / pyridine / 24 h / 0 - 5 °C
3: 54 percent / NaI / acetone / 24 h / Heating
4: 94 percent / NaCN / 72 h / 80 °C
5: 59 percent / 96 percent H2SO4 / methanol / 24 h / Heating
View Scheme
参考文献
Crotti, Paolo; Badalassi, Fabrizio; Di Bussolo, Valeria; Favero, Lucilla; Pineschi, Mauro
Tetrahedron, 2001 , vol. 57, # 40 p. 8559 - 8572
