(2-(甲基氨基)-2-氧代乙基)磷酸二乙酯合成路线 （共 5 条）
反应条件
in methanol; water
72 h; Ambient temperature;
参考文献
Hamdouchi, Chafiq; De Blas, Jesus; Del Prado, Mirian; Gruber, Joseph; Heinz, Beverly A.; Vance, Lori
Journal of Medicinal Chemistry, 1999 , vol. 42, # 1 p. 50 - 59
参考文献
Eli Lilly and Company
Patent: US6358971 B1, 2002 ;
反应条件
in methanol
Acylation;
参考文献
Tamamura, Hirokazu; Yamashita, Masaki; Nakajima, Yutaka; Sakano, Kyoko; Otaka, Akira; Ohno, Hiroaki; Ibuka, Toshiro; Fujii, Nobutaka
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 2983 - 2996
反应条件
lithium diisopropyl amide
multistep reaction; var.: amides; Product distribution;
参考文献
Tay, M.K.; About-Jaudet, E.; Collignon, N.; Savignac, P.
Tetrahedron, 1989 , vol. 45, # 14 p. 4415 - 4430
反应条件
N,N,N',N,-tetramethylethylenediamine; zinc trifluoromethanesulfonate in tetrahydrofuran
T=25°C; Horner-Wadsworth-Emmons reaction; 12 h;
参考文献
Schauer, Douglas J.; Helquist, Paul
Synthesis, 2006 , # 21 p. 3654 - 3660
