2-氰基-2-环庚亚基乙酸乙酯合成路线 （共 6 条）
反应条件
ammonium acetate; acetic acid in benzene
8 h; Heating;
参考文献
Scott; Moore; Zalucky; Nicholson; Lee; Hinko
Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 413 - 417
反应条件
1: iron powder; barium hydroxide / 280 - 290 °C
2: piperidine
View Scheme
参考文献
Vogel
Journal of the Chemical Society, 1928 , p. 2025
反应条件
diethyl ether; aluminium amalgam
参考文献
Royals; Neal
Journal of Organic Chemistry, 1956 , vol. 21, p. 1448,1456
参考文献
Vogel
Journal of the Chemical Society, 1928 , p. 2025
反应条件
1: ethanol; H2O / 5 h / Heating
2: acetic acid, HCl, H2O / 84 h / Heating
3: acetic anhydride / 4 h / Heating
View Scheme
参考文献
Badger; Schwartz; Picker; Dorman; Bradley; Cheeseman; DiMartino; Hanna; Mirabelli
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 2963 - 2970
反应条件
1: amalgamated aluminium; moist diethyl ether
2: alcoholic KOH-solution
View Scheme
参考文献
Vogel
Journal of the Chemical Society, 1928 , p. 2025
