反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 °C / |Inert atmosphere 2.1: 1,4-dioxane / 2 h / 100 °C / |Inert atmosphere 3.1: acetic acid / ethanol / 2 h / 80 °C 4.1: sodium hydroxide / methanol; water / 1 h / 70 °C View Scheme
参考文献
Scott, James S.; Deschoolmeester, Joanne; Kilgour, Elaine; Mayers, Rachel M.; Packer, Martin J.; Hargreaves, David; Gerhardt, Stefan; Ogg, Derek J.; Rees, Amanda; Selmi, Nidhal; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10136 - 10147