(3S)-6,6-二溴-2,2-二甲基青霉烷-3-羧酸 1,1-二氧化物合成路线 （共 11 条）
反应条件
potassium permanganate; phosphoric acid
参考文献
Koteva; Cantin; Neugebauer; Escher
Canadian Journal of Chemistry, 2001 , vol. 79, # 4 p. 377 - 387
反应条件
hydrogen bromide; bromine; sodium nitrite in methanol; dichloromethane
参考文献
Gist-Brocades N.V.
Patent: US4576754 A1, 1986 ;
反应条件
sulfuric acid; bromine; sodium nitrite in dichloromethane; water T=5°C; 1 h;
参考文献
Husinec, Suren; Dragovic, Deana; Stokic, Zdenka; Kojic, Josipa
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 5 p. 1370 - 1375
反应条件
1.1: bromine; sodium nitrite; sulfuric acid / ethyl acetate / 1.67 h / 0 - 10 °C 2.1: sodium hydroxide / ethyl acetate; water / 0.5 h / 5 °C / pH 7 2.2: 0.5 h / -5 °C 2.3: pH 1.23 View Scheme
参考文献
Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, , vol. 42, # 8 p. 1083 - 1086,4
反应条件
sodium hydrogencarbonate in water; ethyl acetate
参考文献
Leo Pharmaceutical Products Ltd. A/S
Patent: US4816580 A1, 1989 ;
反应条件
magnesium in acetic acid n-butyl ester
参考文献
Gist-Brocades N.V.
Patent: US4554104 A1, 1985 ;
反应条件
copper in dichloromethane; water; acetic acid; acetonitrile
参考文献
Alex-Gyogyszer Kutatasi, Fejlesztesi es Tanacsado Korlatot Felelossegu Tarsagag
Patent: US6160112 A1, 2000 ;
US 6160112 A
反应条件
palladium in ethyl acetate
参考文献
Pfizer Inc.
Patent: US4234579 A1, 1980 ;
反应条件
hydrogenchloride in hexane; water; ethyl acetate; acetone
参考文献
Gist-Brocades N.V.
Patent: US4554104 A1, 1985 ;
反应条件
hydrogen; palladium on activated charcoal P=2250.2 - 3750.3 Torr; Ambient temperaturepH 7.0 - 8.0; Product distribution;
参考文献
Lelyak, G. F.; Povalyaeva, E. A.; Filatova, A. A.; Mezentsev, A. S.; Mikhalev, A. V.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 11 p. 847 - 849
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 11 p. 60 - 61
