773837-37-9合成路线 （共 596 条）
反应条件
calcium dihydride; tri-tert-butyl phosphine; Pd2(dba)5 in tetrahydrofuran; acetonitrile T=70°C; 2 h;
参考文献
Ushkov, Alexander V.; Grushin, Vladimir V.
Journal of the American Chemical Society, 2011 , vol. 133, # 28 p. 10999 - 11005
反应条件
tri-tert-butyl phosphine; Pd2(dba)5; zinc in tetrahydrofuran; acetonitrile T=70°C; 2 h;
参考文献
Ushkov, Alexander V.; Grushin, Vladimir V.
Journal of the American Chemical Society, 2011 , vol. 133, # 28 p. 10999 - 11005
反应条件
1: 4-aminoacetophenone With hydrogenchloride; sodium nitrite in water T=0°C; 2: sodium cyanide; CuCN in water T=10 - 60°C;
参考文献
Kvaskoff, David; Bernhardt, Paul V.; Koch, Rainer; Wentrup, Curt
Australian Journal of Chemistry, 2009 , vol. 62, # 9 p. 1068 - 1078
反应条件
copper(l) iodide; potassium iodide; N-methyl-2-(methylamino)ethylamine in toluene T=130°C; 21 h; Inert atmosphere;
参考文献
Corral-Bautista, Francisco; Mayr, Herbert
European Journal of Organic Chemistry, 2013 , # 20 p. 4255 - 4261
反应条件
in N,N-dimethyl-formamide T=130°C; 24 h;
参考文献
Ullah, Nisar; Arafeh, Khaled M.
Tetrahedron Letters, 2009 , vol. 50, # 2 p. 158 - 160
反应条件
in N,N-dimethyl-formamide
参考文献
Akisanya, Joseph; Parkins, Adrian W.; Steed, Jonathan W.
Organic Process Research and Development, 1998 , vol. 2, # 4 p. 274 - 276
反应条件
1: 3-methylsulfanyl-propionaldehyde; 3-(methylseleno)-propionaldehyde With sodium hydrogensulfite in water T=20°C; 0.166667 h; 2: sodium cyanide in water T=20°C; 2 h;
参考文献
US8309763 B2, ;
Page/Page column 7 ;
反应条件
1: (3-cyclopentyloxy-4-methoxyphenyl)methanol With thionyl chloride in 1,2-dichloro-ethane T=20 - 80°C; 0.5 h; 2: sodium cyanide in DMF (N,N-dimethyl-formamide) T=70 - 80°C; 18 h;
参考文献
GLENMARK PHARMACEUTICALS LIMITED
Patent: WO2004/16596 A1, 2004 ;
Location in patent: Page 43 ;
WO 2004/016596 A1
参考文献
Gmelin Handbook: F: PerFHalOrg.9, 5, page 1 - 38
反应条件
copper (I) cyanide; lithium tert-butylate in 1,4-dioxane; m-xylene T=110°C; 12 h; Inert atmosphere; regioselective reaction;
参考文献
Do, Hien-Quang; Daugulis, Olafs
Organic Letters, 2010 , vol. 12, # 11 p. 2517 - 2519
