(S)-2-羟基丙酸 肌乳酸合成路线 （共 142 条）
反应条件
perchloric acid in dichloromethane T=35°C; 5 h;
参考文献
AMATO PHARMACEUTICAL PRODUCTS, LTD.
Patent: EP1484311 A1, 2004 ;
Location in patent: Page 7-8 ;
反应条件
sulfuric acid in dichloromethane; water
参考文献
Kurkin; Belov; Yurovskaya
Chemistry of Heterocyclic Compounds, 2008 , vol. 44, # 9 p. 1123 - 1128
反应条件
copper(l) chloride; diisopropyl-carbodiimide 1.) 4 d, 2.) CH2Cl2, r.t., 18 h; Yield given. Multistep reaction;
参考文献
Decicco, Carl P.; Nelson, David J.; Corbett, Ronald L.; Dreabit, Jason C.
Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4782 - 4785
参考文献
Mathias,L.J.
Synthesis, 1979 , p. 561 - 576
反应条件
in diethyl ether T=0°C;
参考文献
Prosyanik; Mishchenko; Zelenskaya; Forni; Moretti; Torre; Bruekner; Malpezzi; Kostyanovsky
Russian Chemical Bulletin, 1998 , vol. 47, # 7 p. 1359 - 1364
反应条件
thionyl chloride 2 h; Heating;
参考文献
Pitt, Nigel; Gani, David
Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3811 - 3814
反应条件
methanol T=20°C; 24 h;
参考文献
Ansell, Richard J.; Barrett, Simon A.; Meegan, Jonathan E.; Warriner, Stuart L.
Chemistry - A European Journal, 2007 , vol. 13, # 16 p. 4654 - 4664
反应条件
hydrogen in water T=79.84°C; P=45004.5 Torr; Flow reactor;
参考文献
Li, Mengxia; Li, Guangyi; Li, Ning; Wang, Aiqin; Dong, Wenjun; Wang, Xiaodong; Cong, Yu
Chemical Communications, 2014 , vol. 50, # 12 p. 1414 - 1416
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
T=70°C; 8 h; Inert atmosphere;
参考文献
Bai, Jianfei; Zambron, Bartosz K.; Vogel, Pierre
Organic Letters, 2014 , vol. 16, # 2 p. 604 - 607
反应条件
1: in water
T=170°C; P=80 Torr; 3 h;
2: With tin catalyst
T=220°C; P=10 - 15 Torr; Product distribution / selectivity;
参考文献
Hagen, Rainer; Verweij, Adam Bastiaan; Muhlbauer, Udo; Schulze, Joachim; Tietz, Wolfgang; Göhler, Klaus-Dieter; Göhler, Olga Renate
Patent: US2012/149920 A1, 2012 ;
Location in patent: Page/Page column 7 ;
