1.1: AlCl3, aluminium chloride / 1.5 h / 100 °C / Inert atmosphere 2.1: BH3*N,N-diethylanilline; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 4.2: 40 h / -40 °C / Inert atmosphere 5.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 6.2: 0 - 20 °C / Inert atmosphere 7.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere View Scheme

1.1: AlCl3, aluminium chloride / 1.5 h / 100 °C / Inert atmosphere 2.1: BH3*N,N-diethylanilline; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 4.2: 40 h / -40 °C / Inert atmosphere 5.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 6.2: 0 - 20 °C / Inert atmosphere 7.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere View Scheme

potassium carbonate; lithium (hydro)trimethoxyaluminate 1) MeCN, 2) THF, reflux, 40 h; Yield given. Multistep reaction;

暂无反应条件数据

hydrogenchloride in propan-1-ol T=30°C; 1 h; Product distribution / selectivity;

1: in water T=5 - 25°C; 1.33333 h; 2: With hydrogenchloride in water T=5 - 15°C; 1.25 h;

in ethanol T=25 - 78°C; Resolution of racemate;