2,4,6-三羟基苯甲酸合成路线 （共 56 条）
反应条件
zinc(II) chloride; trichlorophosphate T=70°C; Friedel-Crafts reaction; 2.5 h;
参考文献
Wu, Jianlong; Hu, Xuesen; Ma, Lin
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 3 p. 449 - 452
反应条件
bromine 1.) CS2, 80 min, 25 deg C; 2.) water, 70 deg C; Multistep reaction;
参考文献
Kiehlmann, E.; Lauener, R. W.
Canadian Journal of Chemistry, 1989 , vol. 67, p. 335 - 344
参考文献
Will; Albrecht
Chemische Berichte, 1884 , vol. 17, p. 2103
参考文献
v. Hemmelmayr
Monatshefte fuer Chemie, 1911 , vol. 32, p. 787
Monatshefte fuer Chemie, 1913 , vol. 34, p. 372
参考文献
v. Hemmelmayr
Monatshefte fuer Chemie, 1911 , vol. 32, p. 787
Monatshefte fuer Chemie, 1913 , vol. 34, p. 372
反应条件
1: diethyl ether
2: diethyl ether
View Scheme
参考文献
Abbott Laboratories
Patent: US6972340 B2, 2005 ;
反应条件
potassium carbonate in acetone
T=20°C; 18 h;
参考文献
Yuen, Tsz-Ying; Brimble, Margaret A.
Organic Letters, 2012 , vol. 14, # 19 p. 5154 - 5157
参考文献
Sonn; Winzer
Chemische Berichte, 1928 , vol. 61, p. 2303
反应条件
sulfuric acid
T=40°C; 6 h;
参考文献
Ruzicka,E. et al.
Collection of Czechoslovak Chemical Communications, 1972 , vol. 37, p. 1905 - 1907
反应条件
1: 34 percent / trifluoroacetic anhydride / trifluoroacetic acid / 24 h / Ambient temperature
2: 92 percent / triphenylphosphine, DIAD / tetrahydrofuran / 2 h / 0 - 20 °C
3: 85 percent / pyridine / 12 h / 0 °C
4: 87 percent / bis(triphenylphosphine)palladium(II) chloride, Et3N / dimethylformamide / 12 h / 90 °C
5: 100 percent / H2 / Pd(OH)2 / ethanol / 12 h / 760 Torr
6: 91 percent / tetrahydrofuran / 65 h / Heating
7: 4-DMAP, EDCI / CH2Cl2 / 4 h / Ambient temperature
8: TsOH / methanol / 0.5 h / Ambient temperature
9: 100 percent / H2 / 10percent Pd/C / ethanol / 14 h / 760 Torr
View Scheme
参考文献
Dushin; Danishefsky
Journal of the American Chemical Society, 1992 , vol. 114, # 2 p. 655 - 659
