4-(4-羟基苯基)-1-丁醇合成路线 （共 13 条）
反应条件
sodium hydroxide; boron tribromide in dichloromethane; ethyl acetate
参考文献
Gensia Pharmaceuticals, Inc.
Patent: US5395970 A1, 1995 ;
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran; methanol
1.5 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1350792 A1, 2003 ;
Location in patent: Page/Page column 32 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; Inert atmosphere;
参考文献
Fujioka, Hiromichi; Komatsu, Hideyuki; Nakamura, Taeko; Miyoshi, Akihito; Hata, Kayoko; Ganesh, Jnashuara; Murai, Kenichi; Kita, Yasuyuki
Chemical Communications, 2010 , vol. 46, # 23 p. 4133 - 4135
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran
Reflux;
2: With methanol in tetrahydrofuran
3: With acetic acid in tetrahydrofuran; water
pH=3;
参考文献
Novartis AG
Patent: US2010/130506 A1, 2010 ;
Location in patent: Page/Page column 89-90 ;
反应条件
palladium monocarbide
参考文献
Tasaka, Akihiro; Hitaka, Takenori; Matsutani, Etsuya
Patent: US2002/173526 A1, 2002 ;
反应条件
in tetrahydrofuran; methanol; water; ethyl acetate
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: With [bis(acetoxy)iodo]benzene; sodium hydrogencarbonate; H218O in hexafluoroisopropyl alcohol
Inert atmosphere;
2: With lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Fujioka, Hiromichi; Komatsu, Hideyuki; Nakamura, Taeko; Miyoshi, Akihito; Hata, Kayoko; Ganesh, Jnashuara; Murai, Kenichi; Kita, Yasuyuki
Chemical Communications, 2010 , vol. 46, # 23 p. 4133 - 4135
反应条件
T=290 - 295°C; 8 h; Inert atmosphere;
参考文献
Krysin; Egorova; Vasil'Ev
Russian Journal of General Chemistry, 2010 , vol. 80, # 2 p. 275 - 283
反应条件
1: acetic acid / hydrogen bromide; ethyl acetate
2: tetrahydrofuran; methanol; water; ethyl acetate
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
phosphoric acid
T=200°C;
参考文献
Losew; Smirnowa
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 363; engl. Ausg. S. 359
