2-叔丁基-4-羟基茴香醚合成路线 （共 14 条）
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; sodium hydride; N-methylaniline in diethyl ether; xylene T=120°C; 17 h;
参考文献
Synthesis, , # 8 p. 638 - 640
反应条件
1: imidazole / dimethylformamide 2: K2CO3 / acetone / Heating 3: aq. HCl / tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 22, # 5 p. 569 - 571
反应条件
1: With sodium hydroxide in hexane; water T=25 - 50°C; 2.5 - 6.08 h; 2: With sulfuric acid in hexane; water T=25 - 30°C; pH=3 - 4; 0.25 - 0.333333 h; Product distribution / selectivity;
参考文献
WO2007/15260 A2, ;
Page/Page column 7-9 ;
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Journal of Medicinal Chemistry, , vol. 22, # 5 p. 569 - 571
反应条件
1: K2CO3 / acetone / Heating 2: aq. HCl / tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 22, # 5 p. 569 - 571
反应条件
aluminum oxide; silica gel T=170°C; P=12871.4 - 15445.7 Torr;
反应条件
hexane; phosphoric acid
参考文献
Fette und Seifen, , vol. 57, p. 656,658
参考文献
US2792427 , ;
US2676191 , ;
反应条件
sodium hydroxide; potassium hexacyanoferrate(III) in dichloromethane 0.00277778 h; Yields of byproduct given;
参考文献
Hewgill, Frank R.; Legge, Frank
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 12 p. 2863 - 2866
