O,O'-双(2,2,2-三氟乙基)磷乙酸甲酯合成路线 （共 27 条）
反应条件
1-ethyl-piperidine; tin(II) trifluoromethanesulfonate in tetrahydrofuran
T=-78°C; 20 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Sano, Shigeki; Yokoyama, Kenji; Fukushima, Mari; Yagi, Tetsuo; Nagao, Yoshimitsu
Chemical Communications, 1997 , # 6 p. 559 - 560
反应条件
18-crown-6 and KN(TMS)2 in tetrahydrofuran; toluene
T=-78°C; 0.5 h; under nitrogen, effect of reagents and reaction conditions to stereoselectivity of esters; Product distribution;
参考文献
Still, W. Clark; Gennari, Cesare
Tetrahedron Letters, 1983 , vol. 24, # 41 p. 4405 - 4408
反应条件
18-crown-6 and KN(TMS)2 in tetrahydrofuran; toluene
T=-78°C; 0.5 h; under nitrogen, effect of reagents and reaction conditions to stereoselectivity of esters; Product distribution;
参考文献
Touchard, Fracois; Buisine, Olivier; Leguyader, Frederic; Schlama, Thierry; Manfre, Franco
Patent: US2006/100456 A1, 2006 ;
Location in patent: Page/Page column 5 ;
反应条件
sodium hydride in tetrahydrofuran
T=-78°C; 3 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Fischer, Daniel F.; Barakat, Assem; Xin, Zhuo-Qun; Weiss, Matthias E.; Peters, Rene
Chemistry - A European Journal, 2009 , vol. 15, # 35 p. 8722 - 8741
反应条件
1: phosphonoacetic acid P,P-bis(2,2,2-trifluoroethyl)methyl ester With potassium tert-butylate in tetrahydrofuran
T=0°C; Inert atmosphere;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Risgaard, Rune; Nielsen, Simon D.; Hansen, Kasper B.; Jensen, Christina M.; Nielsen, Birgitte; Traynelis, Stephen F.; Clausen, Rasmus P.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 4071 - 4081
反应条件
Yield given. Yields of byproduct given;
参考文献
Engler, Thomas A.; Falter, Wolfgang
Tetrahedron Letters, 1986 , vol. 27, # 35 p. 4115 - 4118
反应条件
1-ethyl-piperidine; tin(II) trifluoromethanesulfonate in dichloromethane
T=0°C; 15 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Rossi, Daniela; Baraglia, Anna Carnevale; Serra, Massimo; Azzolina, Ornella; Collina, Simona
Molecules, 2010 , vol. 15, # 9 p. 5928 - 5942
