4-(3-吡啶)苯甲酸甲酯合成路线 （共 20 条）
反应条件
1: 3-bromo-pyridine With AlCl3, aluminium chloride; magnesium; lithium chloride in tetrahydrofuran
T=25°C; 4 h; Schlenk techniqueInert atmosphere;
2: 4-Bromo-benzoic acid methyl ester With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in tetrahydrofuran
T=50°C; 12 h; Schlenk techniqueInert atmosphere;
参考文献
Bernhardt, Sebastian; Shen, Zhi-Liang; Knochel, Paul
Chemistry - A European Journal, 2013 , vol. 19, # 3 p. 828 - 833
反应条件
potassium phosphate; trans-[Ni(Naph)Cl(PPh3)2]; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=25°C; Suzuki coupling; 24 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Safi, Mehtap; Hoffman, David J.; Fryberger, Miriam C.; George, Aiswaria; Percec, Virgil
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2885 - 2892
反应条件
potassium phosphate; trans-[Ni(Naph)Cl(PPh3)2]; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=25°C; Suzuki coupling; 24 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Safi, Mehtap; Hoffman, David J.; Fryberger, Miriam C.; George, Aiswaria; Percec, Virgil
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2885 - 2892
反应条件
1: 3-hydroxy-pyridine With potassium phosphate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane
T=100°C; 3 h; Inert atmosphere;
2: (4-methoxycarbonylphenyl)-boronic acid With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane
T=100 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Huang, Jie; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2011 , vol. 17, # 14 p. 4038 - 4042
反应条件
palladium diacetate; tris-(o-tolyl)phosphine in toluene
T=20°C; 5 h; Inert atmosphere;
参考文献
Chen, Xu; Zhou, Lingmin; Li, Yimei; Xie, Tao; Zhou, Shuangliu
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 230 - 239
反应条件
1.1: n-butyllithium / diethyl ether / 2 h / -78 °C
1.2: 3 h / -78 °C
2.1: C37H51ClFeNPPd; copper(l) iodide; cesium fluoride / N,N-dimethyl-formamide / 12 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie
Tetrahedron, 2013 , vol. 69, # 2 p. 902 - 909
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
Suzuki-Miyaura reaction; Microwave irradiationHeating;
参考文献
He, Ping; Haswell, Stephen J.; Fletcher, Paul D. I.; Kelly, Stephen M.; Mansfield, Andrew
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, art. no. 133, p. 1150 - 1157
反应条件
2,2'-azo-bisisobutyronitrile; tris-(trimethylsilyl)silane; acetic acid
T=80°C; 32 h;
参考文献
Nunez, Araceli; Sanchez, Aranzazu; Burgos, Carolina; Alvarez-Builla, Julio
Tetrahedron, 2004 , vol. 60, # 29 p. 6217 - 6224
反应条件
1 h; Ambient temperatureIrradiation; Title compound not separated from byproducts;
参考文献
Ohkura, Kazue; Seki, Koh-ichi; Terashima, Masanao; Kanaoka, Yuichi
Tetrahedron Letters, 1989 , vol. 30, # 26 p. 3433 - 3436
参考文献
Otsuka Pharmaceuticals Co., Ltd.
Patent: US6335327 B1, 2002 ;
Location in patent: Page column 90 ;
