1,2-二(溴甲基)苯合成路线 （共 196 条）
反应条件
potassium carbonate in acetone
T=20°C; 3 h;
参考文献
Arumugam, Natarajan; Raghunathan, Raghavachary
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8855 - 8857
反应条件
sodium hydroxide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide
6 h; Heating;
参考文献
Tirado-Rives, Julian; Oliver, Michael A.; Fronczek, Frank R.; Gandour, Richard D.
Journal of Organic Chemistry, 1984 , vol. 49, p. 1627 - 1634
反应条件
diethyl ether; sodium; ethyl acetate
参考文献
Brickwood,D.J. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1978 , p. 1398 - 1414
反应条件
sodium in toluene
24 h; Heating;
参考文献
Domiano, Paolo; Cozzini, Pietro; Claramunt, Rosa Maria; Lavandera, Jose Luis; Sanz, Dionisia; Elguero, Jose
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992 , # 9 p. 1609 - 1620
参考文献
Baker et al.
Journal of the Chemical Society, 1945 , p. 27,29
参考文献
Baker et al.
Journal of the Chemical Society, 1945 , p. 27,29
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=60°C; 48 h; Inert atmosphere;
参考文献
Rajakumar, Perumal; Padmanabhan, Ramar; Ramprasath, Chandrasekaran; Mathivanan, Narayanasamy; Silambarasan, Vaidhyanathan; Velmurugan, Devadasan
Australian Journal of Chemistry, 2013 , vol. 66, # 1 p. 84 - 92
反应条件
hydrogenchloride in methanol
参考文献
Hexachimie Societe Anonyme
Patent: US4166131 A1, 1979 ;
反应条件
1: With sodium; potassium hydroxide in diethyl ether; ethanol; water
5 h; Reflux;
2: With sulfuric acid in methanol
T=20 - 200°C; 1.33333 h; Reflux;
参考文献
Bondada, Lavanya; Rondla, Ramu; Pradere, Ugo; Liu, Peng; Li, Chengwei; Bobeck, Drew; McBrayer, Tamara; Tharnish, Philip; Courcambeck, Jerome; Halfon, Philippe; Whitaker, Tony; Amblard, Franck; Coats, Steven J.; Schinazi, Raymond F.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6325 - 6330
反应条件
1: Na / ethanol; diethyl ether / 5 h / Heating
2: KOH / H2O / 16 h / Heating
3: 0.33 h / 200 °C
4: 94 percent / conc. H2SO4 / 1 h / Heating
View Scheme
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
