1,2,3,4-四氢异喹啉合成路线 （共 340 条）
反应条件
1.1: sodium nitrate; sulfuric acid / 4 - 20 °C 1.2: pH 8 2.1: water; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 h / 20 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; COOK, Brian Nicholas; KOWALSKI, Jennifer A.; LI, Xiang; MARSHALL, Daniel Richard; SCHLYER, Sabine; SIBLEY, Robert; SMITH-KEENAN, Lana Louise; SOLEYMANZADEH, Fariba; SORCEK, Ronald John; YOUNG, Erick Richard Roush; ZHANG, Yunlong
Patent: WO2012/6203 A1, 2012 ;
WO 2012/006203 A1
反应条件
dinitrogen tetraoxide; acetic acid
参考文献
Wegler; Frank
Chemische Berichte, 1937 , vol. 70, p. 1279,1285
参考文献
Wegler; Frank
Chemische Berichte, 1937 , vol. 70, p. 1279,1285
反应条件
1: With sulfuric acid; potassium nitrate T=0 - 20°C; 3 h; 2: With ammonia in water T=0°C; pH=10;
参考文献
CELLZOME AG
Patent: WO2009/62658 A1, 2009 ;
Location in patent: Page/Page column 36 ;
WO 2009/062658 A1
反应条件
1.1: 50 percent / KNO3; H2SO4 / 5 - 20 °C 2.1: 94 percent / Et3N / CH2Cl2 / 1 h / Heating 3.1: FeCl3*6H2O; activated carbon / methanol / 0.33 h / Heating 3.2: 85 percent / NH2NH2*H2O / methanol / 4 h / Heating 4.1: 94 percent / TFA / CH2Cl2 / 0.25 h / Heating 5.1: H2SO4; KNO3 / 0 °C 5.2: 1.1 g / aq. HCl / methanol / 0.83 h / Heating 6.1: aq. NaNO2; aq. HCl / 2 h / 0 °C 6.2: 65 percent / aq. H3PO2 / 10 h / 40 °C 7.1: aq. HCl / methanol / 10 h / Heating View Scheme
参考文献
Zhu, Zhengxiang; Furr, John; Buolamwini, John K.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837
反应条件
sodium acetate; acetic acid 1.) toluene, 1 d, 2.) 4 d, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Dannhardt; Roelcke
Archiv der Pharmazie, 1992 , vol. 325, # 10 p. 671 - 677
反应条件
nickel T=200°C; P=750.06 Torr; 2 h; nitrogen atmosphere, flow system; Yield given. Yields of byproduct given;
参考文献
Okazaki, Hiroshi; Onishi, Kiyotaka; Ikefuji, Yoshio; Tamura, Ryuji
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1990 , # 8 p. 1321 - 1327
反应条件
hydrogen; nickel T=205°C; P=75005.9 Torr; 5.5 h; Yield given. Yields of byproduct given;
参考文献
Okazaki; Soeda; Ikefuji; Tamura; Mochida
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 11 p. 3622 - 3627
反应条件
water; dihydrogen peroxide; iodine in dichloromethane T=20°C;
参考文献
Dhineshkumar, Jayaraman; Prabhu, Kandikere Ramaiah
Organic Letters, 2013 , vol. 15, # 23 p. 6062 - 6065
反应条件
benzophenone in benzene 24 h; Irradiation;
参考文献
Kessar, S V; Mankotia, Anil K Singh; Gujral, Gurjeet
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 5 p. 525 - 526
