4-氯-3-硝基苯甲酸合成路线 （共 122 条）
反应条件
nitric acid; dinitrogen pentaoxide T=25°C; addition of nitronium trifluoromethanesulphonate; Product distribution;
参考文献
Moodie, Roy B.; Sanderson, Andrew J.; Willmer, Richard
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1991 , # 5 p. 645 - 650
反应条件
1: (i) SOCl2, (ii) /BRN= 1236623/, AlCl3 2: NH3 View Scheme
参考文献
Raeymackers; Van Gelder; Roevens; Janssen
Arzneimittel-Forschung/Drug Research, 1978 , vol. 28, # 4 p. 586 - 594
反应条件
(i) SOCl2, (ii) /BRN= 1236623/, AlCl3; Multistep reaction;
参考文献
Raeymackers; Van Gelder; Roevens; Janssen
Arzneimittel-Forschung/Drug Research, 1978 , vol. 28, # 4 p. 586 - 594
反应条件
1.1: water / 4 h / Reflux 1.2: 20 °C / pH 2 2.1: thionyl chloride / N,N-dimethyl-formamide / 0.75 h / Reflux 2.2: 20 - 60 °C 3.1: ammonium formate / palladium on activated charcoal / ethanol / 3 h / Reflux 4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / Reflux 4.2: 10 h / Reflux 5.1: hydrogenchloride; toluene-4-sulfonic acid / ethanol / 48 h / 20 °C 5.2: 10 - 20 °C 5.3: 0.75 h / 50 °C 6.1: potassium carbonate / water; acetone / 0.5 h / 5 °C 6.2: 1 h / 50 °C 6.3: 1 h / Reflux View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash Dhar; SINGH, Ramesh Chandra; RAVAL, Jigar Mukundbhai
Patent: WO2013/111163 A2, 2013 ;
反应条件
oxygen T=500 - 900°C; Oxidation; pyrolysis; Formation of xenobioticscombustion; Product distribution; Further Variations:TemperaturesReagentsair inflow;
参考文献
Vikelsoe; Johansen
Chemosphere, 2000 , vol. 40, # 2 p. 165 - 175
反应条件
1: ethanolic NaOH 2: iron; aqueous HCl View Scheme
参考文献
Farbenfabr. Bayer
Patent: DE825268 , 1950 ;
DRP/DRBP Org.Chem.
反应条件
1: 4-chloro-3-nitro-benzoic acid With Na2S*9H2O in water T=120°C; 0.5 h; 2: acetic acid With acetic anhydride T=20°C; 2 h; Reflux;
参考文献
Huang, Qingqing; Mao, Jialin; Wan, Baojie; Wang, Yuehong; Brun, Reto; Franzblau, Scott G.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6757 - 6767
反应条件
1: 4-chloro-3-nitro-benzoic acid With sodium sulfide 0.333333 h; Heating; 2: acetic anhydride With acetic acid 0.333333 h; Heating;
参考文献
Klar, Ulrich; Buchmann, Bernd; Schwede, Wolfgang; Skuballa, Werner; Hoffmann, Jens; Lichtner, Rosemarie B.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 47 p. 7942 - 7948
反应条件
sodium sulfide; sodium hydroxide; sulfur Erhitzen des Reaktionsprodukts mit Zink-Pulver und Acetanhydrid;
参考文献
Du Pont de Nemours and Co.
Patent: US2647050 , 1949 ;
参考文献
Le Fevre; Turner
Journal of the Chemical Society, 1927 , p. 1117
