3,4-二羟基-2'-氯苯乙酮合成路线 （共 71 条）
参考文献
Dzierzgowski
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1893 , vol. 25, p. 155
Chemische Berichte, 26 Ref. <1893>,589
参考文献
Stephen; Weizmann
Journal of the Chemical Society, 1914 , vol. 105, p. 1051
参考文献
Horii
Yakugaku Zasshi, 1933 , vol. 53, p. 1239,1247;dtsch.Ref.S.256
Chem.Abstr., 1936 , p. 3421
参考文献
Heinzelman; Aspergren
Journal of the American Chemical Society, 1953 , vol. 75, p. 3409,3413
参考文献
Patel; Messer Jr.; Hudson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 13 p. 1893 - 1901
反应条件
hydrogenchloride 1.) isopropyl alcohol, 75 deg C, 5 min; Yield given. Multistep reaction;
参考文献
Brazzell; Kostenbauder
Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 11 p. 1274 - 1281
反应条件
in acetonitrile Ambient temperature;
参考文献
Dominianni, Samuel J.; Yen, Terence T.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2301 - 2306
反应条件
1: Zn; HOAc / tetrahydrofuran
2: 67 percent / HCl / methanol / 0 - 20 °C
View Scheme
参考文献
Mas, Thierry
Synthesis, 2003 , # 12 p. 1878 - 1880
反应条件
in neat (no solvent)
T=100°C; 0.5 h;
参考文献
Bahner,C.T.; Kinder,H.
Journal of Organic Chemistry, 1962 , vol. 27, p. 1464 - 1465
参考文献
Feist; Kuklinski
Archiv der Pharmazie (Weinheim, Germany), 1936 , vol. 274, p. 425,435
