反应条件
1: 1.) Na, 3.) conc. HCl
2: 80 percent / 20percent aq. chloroacetic acid, AcOH / 18 h / Heating
3: 1.) bis(trimethylsilyl)acetamide / 1.) 1,2-dichloroethane, reflux, 35 min, 2.) 1,2-dichloroethane, CH3CN, RT, 18 h
4: NH3(g) / methanol / 18 h / Ambient temperature
View Scheme
参考文献
Orr; Musso; Boswell; Kelley; Joyner; Davis; Baccanari
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3850 - 3856
