1: n-propyl-magnesium chloride With titanium(IV) isopropylate in dichloromethane T=-78°C; 0.166667 h; Inert atmosphere; 2: benzaldehyde With (R)-3-(3,5-diphenylphenyl)-2,2'-dihydroxy-1,1'-binaphthyl in diethyl ether; dichloromethane T=0°C; 3 h; Inert atmosphere; 3: With hydrogenchloride; water in diethyl ether; dichloromethane T=0°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 83, # 1 p. 19 - 32
1: 2-chloro-pyrazine With iron (III) acetylacetonate in tetrahydrofuran Inert atmosphere; 2: n-propyl-magnesium chloride in tetrahydrofuran Cooling with ice-water; 3: With ammonium chloride in tetrahydrofuran; water T=20°C; Inert atmosphere;
参考文献
SANOFI-AVENTIS; LEE, George E.; SHRIMP II, Frederick L.; WEIBERTH, Franz J.
Patent: WO2010/107969 A1, 2010 ;
Location in patent: Page/Page column 6-7 ;
