反应条件
1: 1.) MeONHMe*HCl, i-PrMgCl / 1.) THF, -20 deg C to 0 deg C, 1,5 h, 2.) THF, 0 deg C to 20 deg C, 4 h 2: i-Pr2NEt, DMAP / 72 h 3: 1.) c-Hex2BCl, Me2NEt 3.) H2O2, NaOH / 1.) Et2O, 0 deg C, 2 h, 2.) - 78 deg C, 4 h, 3.) MeOH, 0 deg C, 2 h 4: 82 percent / LiAlH4 / diethyl ether / 0.5 h / -78 deg C to 20 deg C 5: 100 percent / Pb(OAc)4, Na2CO3 / CH2Cl2 / 1 h / 0 °C 6: 100 percent / NaClO2, Na2H2PO4, 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O / 24 h 7: PhSO2Cl, py / 1.) 0 deg C, 10 min, 2.) 4 deg C, 24 h 8: H2 / Pd/C / ethyl acetate / 4 h / 20 °C 9: 84 percent / PPh3, DEAD / tetrahydrofuran / 4 h / 0 °C View Scheme
参考文献
Paterson; Doughty
Tetrahedron Letters, 1999 , vol. 40, # 2 p. 393 - 394
